DoctorEmi.com

CanRex

Regular price $52.00

30 mL  (30-day supply)

  • Helps Support Body Function and Regulation*
  • Helps Support a Healthy Stress Response*
  • Helps Support a Healthy Immune Response*
  • Contains Antioxidant Properties*


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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

CanRex: Oveview

Doctor Emi's CanRex Broad-Spectrum Hemp Extract is certified USDA Organic, non-GMO, and responsibly sourced from aerial plant parts (stalk, stems, seed, and flower) which contain a wide range of beneficial phytocannabinoids, terpenes, and other plant compounds, that when combined, have a beneficial synergistic effect. The phytocannabinoid compounds in CanRex Broad-Spectrum Hemp Extract can support and influence the body’s endocannabinoid system (ECS)⁠—an important neuromodulatory system that plays a role in bodily regulation, relaxation, and equilibrium. Through direct and indirect actions, phytocannabinoids modulate a variety of physiological systems influenced by the ECS which is involved in many aspects of physiology, including a healthy stress response, the immune response, food intake and appetite regulation, and neurological health.*

  • Non-GMO
  • Gluten-Free
  • Vegetarian
  • Allergen-Free
  • Certified glyphosate residue-free
  • USDA Certified Organic
  • Manufactured in a GMP Compliant Facility

DOES NOT CONTAIN: Marijuana

Notice: This product is sourced from organic industrial hemp, which does not exceed 0.3% THC concentration (dry weight).

 Caution: If pregnant, nursing, taking medication or other dietary supplements, consult your healthcare practitioner before use. Keep out of the reach of children.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

CanRex: Directions

As a dietary supplement, take one dropperful (1mL) once daily, or as directed by your healthcare practitioner.

CanRex: Other Ingredients

Organic hempseed oil.

CanRex: Storage

Keep tightly closed in a cool, dry place.

CanRex: In-Depth Information 

The Endocannabinoid System

The endocannabinoid system (ECS) is the most complex regulatory system involved in many aspects of physiology, including a healthy stress response, the immune response, food intake and appetite regulation, and neurological health. In fact, the ECS is the body’s primary regulatory system.[3] This system consists of receptors, endogenous cannabinoids (known as endocannabinoids), and metabolic enzymes.[3] The two major endocannabinoids, anandamide (AEA) and 2-arachidonolyglycerol (2-AG), bind to cannabinoid receptors type 1 (CB1) and type 2 (CB2) located throughout the body, and their biological function is terminated by hydrolyzing enzymes, FAAH and MAGL, respectively. Endocannabinoids are “messengers,” produced and released on demand from the brain and peripheral tissues and activate their targets only when and where needed.[4] As in other systems in the body, factors such as genetics, nutrition, lifestyle, and overall health status can impact endocannabinoid tone and the ability of the ECS to function optimally. Certain foods and activities can help to boost the ECS functions. A healthy diet with balanced essential fatty acids along with medium-to-high intensity aerobic activity have been shown to enhance the activity of the ECS.*[7]

Phytocannabinoids

Phytocannabinoids are naturally occurring plant-based bioactive compounds that can support and influence the body’s endocannabinoid system (ECS). Through direct and indirect actions, phytocannabinoids modulate a variety of physiological systems influenced by the ECS. More than 80 different phytocannabinoids have been identified in different Cannabis species (hemp and marijuana subspecies), including cannabidiol (CBD), cannabigerol (CBG), cannabidiolic acid (CBDA), and many others. In nature, phytocannabinoids work together with other constituents in plants producing synergistic effect on the ECS.*[2]

The Beneficial Interactions of Phytocannabinoids With the ECS

Most of the biological properties related to phytocannabinoids rely on their interactions with the ECS in the body. Phytocannabinoids have been identified to act uniquely on cannabinoid receptors separately and simultaneously and/or to inhibit or activate receptor function.[5] In addition, phytocannabinoids can affect the tissue levels of endocannabinoids. Therefore, phytocannabinoids display unique therapeutic effects by supporting a healthy stress response, neurological health, digestive health, and promoting immune function, among others.*[6]

Terpenes

Terpenes are a group of compounds naturally present in all plants and spices including pepper, cloves, and cinnamon and contribute to their flavor and scent. These molecules are also known to carry a wide array of therapeutic properties.[2]  Terpenes work together with phytocannabinoids to enhance the overall benefit of hemp extract.*[1,2]

The Difference Between Broad-Spectrum Hemp Extract and Hempseed Oil

Broad-spectrum hemp extract is sourced from aerial plant parts (stalk, stems, seed, and flower) of the hemp plant and contains beneficial phytocannabinoids and terpenes. As stated before, it has been suggested that phytocannabinoids and terpenes work together to influence one another and have a synergistic effect on the ECS. Hemp seed oil is extracted only from the seeds of hemp and is mainly used as a source of dietary oil. The levels of phytocannabinoids in hemp seed oil are very low and, therefore, do not promote the same kind of benefits as broad-spectrum hemp extract.*

The Variety of Delivery Formats for Hemp Extract

Hemp extract can be delivered in a variety of different ways. Hemp extract products can be administered sublingually (then swallowed), ingested (as edibles, tinctures, and gel caps), or applied topically. One of the most common methods to deliver hemp extract is in capsules or gel caps. While it provides the most direct and precise method of dosing, oral bioavailability of phytocannabinoids can be low due to first-pass metabolism in the liver, which breaks them down before reaching the circulation.[9]  Hemp extracts in liquid form which are delivered sublingually prior to being swallowed allow the phytocannabinoids to be absorbed through the mouth, which may possibly have higher bioavailability than when delivered through capsules or gel caps.*[10]

Length of Time for Hemp Extract to Take Effect

The uptake of hemp extract depends upon several factors such as current health, metabolism, amount (mg) of phytocannabinoid in hemp extract, and delivery format. It has been shown that following oral consumption of cannabis, the onset of action ranges between 30–90 minutes, and plasma levels of cannabinoids peak at around 1 to 6 hours after consumption.[11, 12]  The best source of info on what to expect in relation to time and effect may come from speaking with an experienced practitioner.*


*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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References

1. Russo E. Br J Pharmacol. 2011;163:1344–1364.
2. Andre CM et al. Front Plant Sci. 2016;7:19.
3. Aizpurua-Olaizola O et al. Drug Discov Today. 2017;22(1):105–110.
4. Di Marzo V et al. Nat Rev Drug Discov. 2004;3(9):771–784.
5. Maroon J et al. Surg Neurol Int. 2018;9:91.
6. Andre CM et al. Front Plant Sci. 2016;7:19.
7. McPartland JM et al. PLoS ONE. 2016;9(3):e89566.
8. Stahl E et al. J Agri and Food Chem. 1980;28(6):1153–1157.
9. Ujvary I et al. Cannabis Cannabinoid Res. 2016;1(1):90–101.
10. Mannila J et al. J Pharm Sci. 2007;96(2):312–319.
11. Nahtigal I et al. J Pain Manage. 2016;9(4):481–491.
12. MacCallum C. A. et al. Euro J Int Med. 2018:49, 12–19.


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