DoctorEmi.com

Collagen Supporting Natural Bone Health Formula

Regular price $72.95

60 pkt. (30-day supply)

  • Provide a Multifaceted Approach to Bone Maintenance and Strength*
  • Provide Foundational Support with Choline-Stabilized Orthosilicic Acid (ch-OSA®)*
  • Support Bone Collagen Formation, Bone Mineral Density, and Bone Calcium Binding Sites*
  • Provide a Complementary Combination of Micronutrients*

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.


Collagen Supporting Natural Bone Health Formula: Overview

Doctor Emi's Collagen Supporting Natural Bone Health Formula is a comprehensive, convenient, and cost-effective dietary supplement that supports healthy bones, cartilage, and ligaments. Each packet provides the following: two capsules containing a combination of microcrystalline hydroxyapatite concentrate (MCHC) from Ossopan 1100™, vitamin D3, and vitamin K2 along with one capsule of choline-stabilized orthosilicic acid (ch-OSA®‡).*

Bone is composed of a calcium-based mineral complex and an organic material known as collagen. A somewhat flexible and fibrous protein, collagen appears to be a key factor in a bone’s ability to withstand sudden impact. The quantity and health of collagen determines the bone’s “toughness,” while the mineral content determines its strength and stiffness.*

Collagen Supporting Natural Bone Health Formula contains choline-stabilized orthosilicic acid, a well-absorbed form of silicon that has been clinically tested. Silicon-dependent enzymes link together single chains of amino acids to synthesize collagen fibers. The surfaces of these collagen fibers act as the binding sites for the MCHC. The more surface area available to the MCHC to bind to, the more flexible the bone.*

MCHC, a proprietary, standardized, and safe-source bone extract from New Zealand bovine, contains a crystalline calcium and phosphorus matrix in the ideal physiological ratio of 2:1, plus bioactive growth factors and type I collagen. As a source of calcium, MCHC contributes to the production and maintenance of bone structure, a function supported by vitamins D3 and K2. Amino acids, glycosaminoglycans, and a broad range of essential trace elements are also present.*

Combine ch-OSA and MCHC with significant levels of vitamins D3 and K2, and the result is a unique package that addresses quantity and quality of bone, and supports overall bone strength and health.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

  • Non-GMO
  • Soy-Free
  • Gluten-Free
  • Manufactured in a GMP Compliant Facility

DOES NOT CONTAIN: wheat, gluten, yeast, soy protein, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Collagen Supporting Natural Bone Health Formula: Directions

Consume the contents of one packet with a meal, one to two times daily, or as directed by your healthcare practitioner.

Caution

Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Consider total vitamin K intake (food + supplements) if you are taking blood-thinning medication. Present studies show that 45 mcg of MK-7 from VitaMK7™ daily is not likely to interfere with blood-thinning medicines. Do not use if tamper seal is damaged.

Collagen Supporting Natural Bone Health Formula: Other Ingredients

Ossopan 1100 with viatmins D3 and K2 Capsule

HPMC (capsule), vegetable stearic acid, vegetable magnesium stearate, medium-chain triglycerides, and silica.

ch-OSA capsule 

  • Microcrystalline cellulose, HPMC (capsule), and purified water. VitaMK7 is a trademark of Gnosis S.p.A. 
  • † Microcrystalline Hydroxyapatite Concentrate 
  • ‡Choline-stabilized orthosilicic acid (ch-OSA) is a registered trademark of and manufactured by Bio Minerals n.v., Belgium. Produced under US patents 5,922,360; 7,968,528; and 8,771,757.

Collagen Supporting Natural Bone Health Formula: Storage

Keep closed in a cool, dry place out of reach of children.

Collagen Supporting Natural Bone Health Formula: In-Dept Information

Bone health is dependent on a constant supply of micronutrients for maintenance and repair. Instead of adopting a single-nutrient, unbalanced approach to supplementation, Doctor Emi utilizes an array of complementary, well-researched nutrients in her formulas to build and maintain bone over time.*

Doctor Emi's Collagen Supporting Natural Bone Health Formula features ch-OSA® (Silicon as Choline-Stabilized Orthosilicic Acid), a patented, stabilized, readily absorbed, bioactive form of silicon called orthosilicic acid. Decades of research suggest that there is a strong, positive association between dietary silicon and bone mineral density (BMD).[1] The mechanisms of action appear to be silicon’s support of collagen synthesis and stabilization, extracellular matrix mineralization, and connective tissue integrity.[2,3] In cell-line studies, orthosilicic acid has been found to stimulate type I collagen synthesis.[4] Type I collagen is a dense, heavily cross-linked protein that creates an extremely high tensile strength[5] and contributes to bone strength and flexibility. These strong collagen strands are believed to create core-post “binding sites” for calcium and other bone minerals.[6-8] A 12-month, randomized, double-blind, placebo-controlled (RDBPC) trial suggested that supplementing with ch-OSA conferred an additional benefit to a calcium/vitamin D regimen by improving bone formation markers and femoral neck T-scores.*[9]

Vitamin D3 Cholecalciferol (vitamin D3) is the form of vitamin D that is endogenously synthesized in skin during exposure to sunlight. Unfortunately, several factors can limit this production including smog, sunblock, and geographic location. For many individuals, exogenous supplementation may be beneficial. Vitamin D plays a role in bone metabolism, BMD, and calcium/phosphorus status; researchers suggest that vitamin D supplementation may decrease bone turnover and increase BMD.[10] Several randomized placebo-controlled trials with vitamin D and calcium showed significant improvement in maintenance of bone integrity.[10] One randomized, population-based, three-year trial indicated that supplementation with vitamin D (800 IU/d) and calcium (1000 mg/d) had a positive and statistically significant impact on total body bone integrity.[11] A pooled analysis evaluating 11 RDBPC trials concluded that vitamin D supplementation (>800 IU daily) was favorable in maintaining hip and nonvertebral bone integrity in those aged 65 and older.*[12]

Calcium as Microcrystalline Hydroxyapatite Concentrate (MCHC) Collagen Supporting Natural Bone Health Formula contains Ossopan MCHC, a premium, standardized bone extract from New Zealand bovine. This hydroxyapatite matrix comprises calcium, phosphorus, magnesium, bioactive growth factors, type I collagen, amino acids, glycosaminoglycans, and a broad range of essential trace elements. Hydroxyapatite is essentially a mineralized matrix that promotes resistance to compression and can be compared to reinforced concrete.[5] Decades of scientific studies suggest that Ossopan supplementation fundamentally supports BMD and bone health.[13-16] A meta-analysis of six controlled studies suggested that hydroxyapatite was significantly more effective than calcium carbonate in supporting bone structure and BMD.*[17]

Doctor Emi's Collagen Supporting Natural Bone Health Formula contains MK-7, a bioactive, bioavailable form of vitamin K.[18] Vitamin K plays an active role in bone metabolism, calcium utilization, and activation of osteocalcin (the protein needed to bind calcium to the mineral matrix in bone). Vitamin K supports bone integrity by moderating the synthesis of prostaglandin E2 and interleukin-6 by osteoclasts.[19,20]. A three-year study utilizing 180 μg/d of MK-7 concluded that MK-7 significantly improved vitamin K status, supported bone mineral content and BMD, and favorably supported bone strength and integrity in healthy postmenopausal women.*[21]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Learn More: Low Bone Density? Improve Bone Health Naturally!

Learn More: Vitamin K2 with D3: a Synergistic Duo in Bone Health

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References

1. Jugdaohsingh R. Silicon and bone health. J Nutr Health Aging. 2007 MarApr;11(2):99-110.
Review. [PMID: 17435952]

2. Silica. Natural Standard Database. https://naturalmedicines.therapeuticresearch.com/  Accessed June 12, 2013.

3. Gaby A. Nutritional Medicine. Concord, NH: Frtiz Perlberg Publishing; 2011.

4. Reffitt DM, Ogston N, Jugdaohsingh R, et al. Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. Bone. 2003 Feb;32(2):127-35. [PMID: 12633784]

5. Blair HC, Robinson LJ, Huang CL, et al. Calcium and bone disease. Biofactors. 2011 May-Jun;37(3):159-67. Review. [PMID: 21674636]

6. Calomme MR, Vanden Berghe DA. Supplementation of calves with stabilized orthosilicic acid. Effect on the Si, Ca, Mg, and P concentrations in serum and the collagen concentration in skin and cartilage. Biol Trace Elem Res. 1997 Feb;56(2):153-165. [PMID: 9164661]

7. Calomme MR, Geusens P, Demeester N, et al. Partial prevention of long-term femoral bone loss in aged ovariectomized rats supplemented with cholinestabilized orthosilicic acid. Calcif Tissue Int. 2006, Apr;78(4): 227-232. [PMID: 16604283]

8. Viguet-Carrin S, Garnero P, Delmas PD. The role of collagen in bone strength. Osteoporos Int. 2006;17(3):319-36. Review. [PMID: 16341622]

9. Spector TD, Calomme MR, Anderson SH, et al. Choline-stabilized orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial. BMC Musculoskelet Disord. 2008 Jun 11;9:85. [PMID: 18547426]

10. Lips P, van Schoor NM. The effect of vitamin D on bone and osteoporosis. Best Pract Res Clin Endocrinol Metab. 2011 Aug;25(4):585-91. Review. 
[PMID: 21872800]

11. Kärkkäinen M, Tuppurainen M, Salovaara K, et al. Effect of calcium and vitamin D supplementation on bone mineral density in women aged 65-71 years: a 3-year randomized population-based trial (OSTPRE-FPS). Osteoporos Int. 2010 Dec;21(12):2047-55. [PMID: 20204604]

12. Bischoff-Ferrari HA, Willett WC, Orav EJ, et al. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med. 2012 Jul 5;367(1):40-9. [PMID: 22762317]

13. Pelayo I, Haya J, De la Cruz JJ, et al. Raloxifene plus ossein-hydroxyapatite compound versus raloxifene plus calcium carbonate to control bone loss in postmenopausal women: a randomized trial. Menopause. 2008 NovDec;15(6):1132-8. [PMID: 18791486]

14. Castelo-Branco C, Pons F, Vicente JJ, et al. Preventing postmenopausal bone loss with ossein-hydroxyapatite compounds. Results of a two-year, prospective trial. J Reprod Med. 1999 Jul;44(7):601-5. [PMID: 10442322]

15. Albertazzi P, Steel SA, Howarth EM, et al. Comparison of the effects of two different types of calcium supplementation on markers of bone metabolism in a postmenopausal osteopenic population with low calcium intake: a double-blind placebo-controlled trial. Climacteric. 2004 Mar;7(1):33-40. [PMID: 15259281]

16. Rüegsegger P, Keller A, Dambacher MA. Comparison of the treatment effects of ossein-hydroxyapatite compound and calcium carbonate in osteoporotic females. Osteoporos Int. 1995 Jan;5(1):30-4. [PMID: 7703621]

17. Castelo-Branco C, Ciria-Recasens M, Cancelo-Hidalgo MJ, et al. Efficacy of osseinhydroxyapatite complex compared with calcium carbonate to prevent bone loss: a meta-analysis. Menopause. 2009 Sep-Oct;16(5):984-91.[PMID: 19407667]

18. Schurgers LJ, Teunissen KJ, Hamulyák K, et al. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood. 2007 Apr 15;109(8):3279-83. [PMID: 17158229]

19. Weber P. Management of osteoporosis: is there a role for vitamin K? Int J Vitam Nutr Res. 1997;67(5):350-6. [PMID: 9350477]

20. Shearer MJ. The roles of vitamins D and K in bone health and osteoporosis prevention. Proc Nutr Soc. 1997 Nov;56(3):915-37. [PMID: 9483660]

21. Knapen MH, Drummen NE, Smit E, et al. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int. 2013 Mar 23. [Epub ahead of print] [PMID: 23525894]
  

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